The paper examined the effect of trade liberalization on non-oil exports in Sub-Saharan African countries (SSA). The study used secondary annual panel data which span the period 2004 to 2023.The panel data was analyzed with the aid of the Pooled Mean Group (PMG) estimator. The variables incorporated in the study are non-oil output as proxy for non-oil exports which is the dependent variable, while trade openness, inflation, foreign direct investment, exchange rate, and institutional quality, all serve as the independent variables. The outcome of the findings, revealed that in the long run and short run, trade openness is found to have a positive relationship with non-oil export with a coefficient of 0.0035 and 0.1270 respectively, and is found to be statistically significant in the short run, while in the long run it demonstrated an insignificant effect on non-oil export. FDI, inflation, institutional quality and exchange rate having a negative coefficient value of -0.062, -0.018, -0.099, and -2.929 respectively indicated an inverse association with non-oil exports in the long run, and are statistically significant, except for FDI which possess an insignificant effect on non-oil exports. In short run both exchange rate, institutional quality and inflation are statistically insignificant, except for FDI which is significant. The study recommends that government and various stakeholders in SSA countries should implement trade liberalization policies by reducing tariffs, simplify customs procedures, and increase market access for non-oil exporters, also complementary policies as investment in infrastructure, human capital to support non-oil export growth should be implemented.