In today’s economy and the rising cost of living, we attempt to investigate the impact of road transportation investment and its resultant effect on economic growth in Cross River State. Primary method of analysing and estimating the specified equation were employed. The result from the estimated analysis revealed that a positive and significant relationship between road transportation investment and the delivery of agricultural outputs in Cross River State. The result further revealed that a positive and significant relationship between unemployment and road transportation in Cross River State, Based on the findings, the study recommended that the government should put in place measures to rehabilitate, reconstruct and repair bad roads both in urban and rural areas. By so doing, this will help the movement of agricultural products freely from rural to urban areas thereby making agricultural produce cheaper and affordable for all. The study also recommended that the government should put in place measures aimed at developing and adding more innovations and creativity to the road transportation sector. By so doing, this will reduce unemployment and reduce youth restiveness especially in the rural areas.