Maternal mortality is still high in Nigeria, even though government has been spending over the years on health. Hence, this study examined the effect of health care expenditures on maternal mortality in Nigeria between 1991 and 2021.The study made use of secondary data sourced from World Development Indicators of the World Bank and the Statistical Bulletin of Central Bank of Nigeria. The data were analyzed using descriptive statistics and Autoregressive Distributed Lag (ARDL) model. This was adopted as the estimation technique because the variables were integrated with mixed order of integration I (0) and I(1). After controlling for relevant covariates like female literacy rate, female per capita income and poverty rate, the study revealed that health care expenditure plays a vital role in reducing incidences of maternal mortality in Nigeria both in the short-run and long-run periods. Therefore, the study recommends that governments at all levels in Nigeria should put more resources in the health care sector especially on the area of maternal health.