Small and medium-sized enterprises (SMEs) are often at the forefront of business growth as they play a pivotal role in job creation due to their agility and potential for rapid expansion. This study examined the relationship between business growth and employment generation in Jos, Plateau State. Quantitative research design was adopted for this study. The population of the study is 268 active SME operators in Jos metropolis. Yamane formula was used to derive sample size of 160. Stratified random sampling technique was used for sample selection. Primary data was used for the study. Ordinary least square Regression analysis was used to analyze the data. The result shows that there is significant relationship between business growth and employment generation among the SMEs in Jos. Thus, we recommend that Government should initiate policies aimed at harnessing the potential of SMEs businesses in order to generation employment in Nigeria. This will enhance economic growth, poverty reduction and improve the living standard.