The study examines the influence of entrepreneurship mindset on Small and Medium Enterprises Performance in Yola metropolis, Adamawa State. The study was premised on the fact that poor performance of business could emanate from other factors like a lack of initiative and an administrative framework or linkage to support and sustain business growth, which to a large extent affect the profit margins of the enterprises. This poor performance of business will have an influence on the economy in different ways: bureaucratic corruption, absence of social consensus on important macroeconomic policy issues, and low profitability. The main objective of this study is to examine the influence of entrepreneurship development on small and medium enterprises performance in Yola metropolis, Adamawa State. The study is a cross sectional design in which data were collected through a questionnaire administered to 335 respondents, of which only 324 were successfully returned and valid. The collected data was subjected to inferential analyses, and hypotheses were tested using multiple regression analysis at a significance level of 0.05. The findings revealed that an entrepreneurial mindset has a significant and positive influence on business growth (b = 0.391, t = 8.134, p = 0.000). The study recommended that there is a need for entrepreneurs to develop their mindset in planning their day-to-day business activities, as this will help them to have a positive attitude to meet the changing demands of current customers in their business and increase their independence and their ability to reason beyond the immediate situation and plan for the future as a result of good thinking.