Financial inclusion and bank’s profitability are critical components of a country’s economic growth and development. This study examines the impact of financial inclusion on the profitability of listed Deposit Money Banks in Nigeria using panel data from 10 sampled banks for ten years (2013-2022), proxied by credit accessibility, digital payment usage, bank account penetration and point of sale, on bank profitability. The data were extracted from the annual accounts and reports of the sample banks. Multiple regression technique was employed in analyzing the data. Based on the analyses of the data collected, the study found that credit accessibility and digital payment usage are positive and significant in influencing the profitability of the listed banks. However, bank account penetration is negative but significantly related to the profitability of the listed banks while point of sales has an insignificant negative relationship with the profitability of listed deposit money banks in Nigeria. The study concludes that financial inclusion can improve the profitability of listed DMBs in Nigeria. Based on the findings obtained from this study, the study recommended that the management of the banks should encourage credit accessibility and digital payment usage to maximize their profitability.