ABSTRACT The health sector globally is still devoting more energy and resources in terms of advocacy, prevention, control and management of malaria and tuberculosis with the aim to eradicate their spread. However, the world and Nigeria in particular is not on track to reach critical targets of the WHO Global technical strategy for reducing global malaria case incidence by 90% or more by 2030; and reducing the global malaria mortality rate by 90% or more as well as ending tuberculosis (TB) by 2030 which are among the target of sustainable development goals. Against this background, this study examine the impact of malaria and tuberculosis on economic growth in Nigeria. Secondary data covering the period from 1986 to 2023 were used for the study. The data set were first tested for stationarity properties to avoid spurious regression estimates using Augmented Dickey Fuller (ADF) unit root tests. In addition, the study employed Autoregressive Distributed Lag Model (ARDL) Bound test technique to examine long-run relationship and impact of malaria incidence, tuberculosis and healthcare literacy on economic growth. The ARDL Bound testing confirmed that, there is long-run relationship between malarial incidence, tuberculosis, healthcare literacy and economic growth in Nigeria. This was further confirmed by the ARDL long-run coefficients which indicated that; malaria incidence and healthcare literacy (HLR) have positive and significant impact on economic growth in Nigeria. A percentage increase in malarial incidence and healthcare literacy increase economic growth by 42 units and 13 units respectively.. On the other hand, the study confirmed that, tuberculosis (TBC) has a significant negative impact on economic growth (GDP) as a unit increase in the incidence of tuberculosis (TBC) would reduce economic growth (GDP) by about 20 units. In line with the findings, the study recommended among other measures that; government should intensify effort in combating malaria and tuberculosis while providing free treatment for the households especially the rural dwellers to relief them of those curative costs which depletes average household income to enable them contributes meaningfully in the production of goods and services in the economy.